A decade-long study from Weill Cornell Medicine shows that endoscopic sleeve gastroplasty (ESG) delivers sustained long-term weight loss without the need for weight-loss medications. Among 110 patients who only had ESG, the average total body weight loss (TBWL) at 10 years was 10.5%, with over half maintaining at least 5% TBWL. ESG was well tolerated, with only mild and transient side effects. The findings reinforce ESG’s effectiveness and safety as a durable, minimally invasive obesity treatment option.